EFFECT OF RADIOTHERAPY-INDUCED ALTERATION OF INDIVIDUAL RADIOSENSITIVITY ON DEVELOPMENT OF SIDE EFFECT IN CANCER PATIENTS

Volume 30, Number 7 (2020)

Olga Sevriukova, Aista Plieskienė, Kamilė Guogytė, Rima Ladygienė, Julius Žiliukas, Vinsas Janušonis Abstract Ionizing radiation is commonly used for cancer treatment. Human response to the same dose of ionizing radiation can vary among individuals, therefore individual radiosensitivity (IRS) was proposed to be an important factor for development of radiotherapy (RT) related side effects. Ionizing radiation especially…

Safety And Toxicity Combining Radiation Therapy With A Biologic Therapy In Locally Advanced Head And Neck Squamous Cell Cancer At The Klaipeda University Hospital Clinical Practice

Volume 26, Number 5 (2016)

Jurga Remeikienė, Aista Plieskienė, Alvydas Česas, Jūratė Kasnauskienė Abstract We retrospectively reviewed head and neck cancer cases, treated cetuximab concomitantly with radiotherapy in Klaipeda University Hospital. Comparison of acute side efects of bioradiotherapy and survival analysis. Keyword(s): cetuximab; radiotherapy; head and neck cancer; toxicity; risk factor; HPV. DOI: 10.5200/sm-hs.2016.079 Full Text: PDF Back

Micronuclei And G2 Assays For Assessment Of Chromosomal Radiosensitivity As Assistant Tool In Radiotherapy: Method-Comparison Study

Volume 26, Number 5 (2016)

Kamilė Guogytė, Aista Plieskienė, Olga Sevriukova, Rima Ladygienė, Julius Žiliukas, Vinsas Janušonis Abstract Radiation therapy is widely used for cancer treatment. Medical application of ionizing radiation can cause different responses in human depending on individual radiosensitivity. Therefore, assessment of individual radiosensitivity could be proposed as assistant tool in optimizing radiotherapy. The cytokinesis- block micronucleus and…

Long-Term Results In Cervical And Uterine Cancer Patients Treated With Combined Photon And Neutron Radiotherapy

Volume 26, Number 4 (2016)

Vitalija Samerdokienė, Konstantinas Povilas Valuckas, Ernestas Janulionis, Vydmantas Atkočius Abstract During the long period of time radiation therapy used to cure oncological diseases can cause second primary malignancies (SPM) . In this investigation the spread of SPM was evaluated between 1143 pts treated with radiation therapy (RT) during the period of 1989-1999 with cervix uteri…

Radiosensitivity Of Chondrosarcomas: A Case Of Spinal Chondrosarcoma

Volume 25, Number 4 (2015)

Aista Plieskienė Abstract Chondrosarcomas are slow-growing, malignant mesenchymal tumours characterized by the formation of cartilage by the tumour cells, high-grade malignant lesions with aggressive local behavior and metastatic potential. As chondrosarcomas grow slowly, with a relatively low fraction of dividing cells, and radiotherapy acts at dividing cells, chondrogenic tumors are considered relatively radiotherapy resistant. Radiotherapy…

A New Approach In The Study Of Individual Radiosensitivity In Cancer Patients

Volume 25, Number 4 (2015)

Aista Plieskienė, Rima Ladygienė, Žygimantas Vaisiūnas, Kamilė Guogytė, Vinsas Janušonis, Julius Žiliukas Abstract Radiotherapy is used with curative intention in most cancer patients. Individual radiosensitivity has a crucial impact on radiotherapy related side effects. Analysis of cytogenetic damage in peripheral blood lymphocytes induced by ionizing radiation is commonly used for biodosimetry. The applicability of the…

Giant Cell Tumors. Clinical Case

Volume 25, Number 4 (2015)

Alvydas Česas, Rugilė Česaitė Abstract Giant cell tumor (GCT) is a rare, benign tumor, however shows a tendency for significant bone destruction, local recurrence and occasionally metastasis. Most patients present with slowly progressive pain, local swelling and pathologic bone fractures. Local treatment is the most effective treatment for giant cell tumors. Wide local excision is…

Evidence-Based Strategy For The Prevention And Management Of Head And Neck Cancer Therapy-Induced Oral Mucositis

Volume 24, Number 2(93) (2014)

Nora Šiupšinskienė Abstract The article includes comprehensive description of radiation and chemotherapy induced oral mucositis in the management of head and neck cancer. Its’ ascribes the mucositis severity grading according the classification of World Health Organization, risk factors for mucositis and also symptoms and signs. Differential diagnosis and summarise data on the sequences of oral…