NAFLD PATHOGENESIS AND CLINICAL ASSOCIATIONS WITH CARDIOVASCULAR DISEASES

Julija Valaitienė Abstract Non-alcoholic fatty liver disease (NAFLD) is an expan­ding issue in prevention and treatment. The central patho­logical processes of NAFLD comprise pathological lipid accumulation resulting in insulin resistance, oxidative stress, mitochondrial dysfunction, inflammation, and endoplasmic reticulum stress. NAFLD is firmly associ­ated with a raised risk of major cardiovascular events. This literature review seeks…

IMPACT OF CONTACT SYSTEM ON CARDIOVASCULAR DISEASES

Julija Valaitienė Abstract Contact and intrinsic coagulation pathway components are involved in pathological thrombus formation. In addi­tion to coagulation, contact system activation is involved in anti/profibrinolytic and inflammatory processes that can contribute to the atherosclerotic and thrombotic en­vironment, leading to cardiovascular diseases. This lite­rature review concerns the role of the contact system on cardiovascular diseases…