Julija Valaitienė


Non-alcoholic fatty liver disease (NAFLD) is an expan­ding issue in prevention and treatment. The central patho­logical processes of NAFLD comprise pathological lipid accumulation resulting in insulin resistance, oxidative stress, mitochondrial dysfunction, inflammation, and endoplasmic reticulum stress. NAFLD is firmly associ­ated with a raised risk of major cardiovascular events. This literature review seeks to overview the pathophy­siological mechanisms of NAFLD and provide proof of a connection between NAFLD and an augmented risk of cardiovascular complications.

Keyword(s): non-alcoholic fatty liver disease, insulin resistance, oxidative stress, inflammation, cardiovascular diseases.

DOI: 10.35988/sm-hs.2024.129
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