Julija Valaitienė


Contact and intrinsic coagulation pathway components are involved in pathological thrombus formation. In addi­tion to coagulation, contact system activation is involved in anti/profibrinolytic and inflammatory processes that can contribute to the atherosclerotic and thrombotic en­vironment, leading to cardiovascular diseases. This lite­rature review concerns the role of the contact system on cardiovascular diseases and accentuates the potential of coagulation factors FXII (FXII) and FXI (FXI) as targets for antithrombotic therapy.

Keyword(s): contact system, FXII, FXI, thrombosis, inflammation.

DOI: 10.35988/sm-hs.2024.126
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