IMMUNE MEDIATED SIDE EFFECTS OF PEMBROLIZUMAB AND NIVOLUMAB THERAPY: PATHOPHYSIOLOGY, GENETIC CONTRIBUTIONS AND CLINICAL SIGNIFICANCE

Volume 35, Number 7 (2025)

Karamello Halak, Yuseph Mohamed, Armantas Gintautas Abstract Pembrolizumab and nivolumab are examples of immune checkpoint inhibitors (ICIs) drugs that are cancer trea­ting drugs that reactivate antitumor immune responses. But they result in immune related side effects (irAEs) that are typically multisystemic and unpredictable. In additionally referring to advanced artificial intelligence (machine learning) for early detection…

GUT AND SKIN MICROBIOME IN PATIENTS WITH HIDRADENITIS SUPPURATIVA

Volume 34, Number 5 (2024)

Greta Stravinskaitė, Giedrė Lijana Gajauskienė Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that profoundly diminishes the quality of life for the affected patients, and is characterized by persistent purulent lesions in anatomical areas prone to constant skin friction, such as the armpits, groin, buttocks and breasts. The HS pathophysiology encompasses an array…