Polycystic ovary sindrome (PCOS) is heterogenous clinical syndrome associated with endocrine, reproductive and metabolic disturbances. Study objective was to evaluate impact of PCOS on young women‘s health. This was the first such kind study in Lithuania.
Methods. Study was performed at Anatomy, histology and antropology department of Vilnius University between 2007 and 2011. 197 young 20–35 years old women were examined: 116 of them satisfied Rotterdam criteria and were included into PCOS group, 81 women were included into control group.
Results. PCOS patients presented higher LH, LH/FSH, testosterone and FAI level with discriminant point at 1,39 units for LH/FSH, 1,33 nmol/l for testosterone and 2,25 units for FAI. There were no differences in menarche age between groups, but 2/3 of PCOS patient had menstrual disturbances from the beginning of periods. 91,3% of PCOS patients had polycystic ovary morphology on ultrasound, 37,1% could not conceive. PCOS patients‘ weight was 16 kg higher and waist circumference was 12 cm higher comparing with control. PCOS patients had higher glucose concentration independently of body mass, higher LDL cholesterol, triglicerides and HOMA-IR and lower HDL cholesterol level than control. Metabolic syndrome was detected almost for a quarter of PCOS patients. Waist circumference higher 83,5 cm showed the best metabolic syndrome discriminant ability for PCOS women.
Conclusions. Hypothalamus, pituitary and ovaries relations are impaired in PCOS patients. More than half of PCOS women are overweight and one third of them are obese. Obesity aggravates their metabolic and reproductive status: more than half of obese PCOS patients has metabolic syndrome. Odds ratio for infertility of obese PCOS women is 2,73 higher than non-obese PCOS patients. The following features associated with increased cardiovascular risk are common in PCOS patients: higher glycemia, impaired fasting glycemia and glucose tolerance, abdominal obesity, dyslipidemia and increased blood pressure. Classic PCOS phenotypes present more intense metabolic disturbances, while normoandrogenic PCOS phenotype presents rates similar to control.
Keyword(s): polycystic ovary syndrome, reproductive health, body mass index, metabolic sindrome.
Full Text: PDF