Danguolė Raulinaitytė, Rasa Ugenskienė, Rasa Jančiauskienė, Elona Juozaitytė, Laura Kairevičė Kairevičė


Colorectal cancer results from the intracellular accumulation of both genetic and epigenetic changes that transform normal glandular epithelium into invasive adenocarcinoma. Each stage of colorectal tumor formation involves different genes. It is believed that changes of MMR and APC genes are important for the initiation, KRAS and BRAF – for further development of the tumor, Tp53, DCC and other genes are important for the malignization process. Normal cells can turn malignant due to chromosomal instability, microsatellite instability and methylation of CpG islands. These genome alterations usually determine the activation of oncogenes, inactivation of tumor suppressor genes or changes in DNA repair genes.

Article in Lithuanian


Keyword(s): Colorectal cancer; genes; molecular mechanisms
DOI: 10.5200/346
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