Expression and Activity of Nadph Oxidase 4 (Nox4) is Related to Antiapoptotic Activity of Human Pancreatic Adenocarcinoma Cells

Volume 25, Number 2(99) (2015)

Aurelija Maziukienė, Aldona Jakštaitė, Giedrė Šilkūnienė, Kristina Kmieliūtė, Antanas Gulbinas, Žilvinas Dambrauskas Abstract Pancreatic adenocarcinoma is one of the most aggressive human malignancies with high mortality rates. Low survival rates are due to late diagnosis at advanced stages of the disease. High invasiveness and chemoresistance of pancreatic adenocarcinoma at least partially could be related to…

Expression and Function of Cugbp2 and Hur Proteins in Human Pancreatic Adenocarcinoma Pathogenesis

Volume 24, Number 6(97) (2014)

Aldona Jakštaitė, Aurelija Maziukienė, Giedrė Šilkūnienė, Antanas Gulbinas, Žilvinas Dambrauskas Abstract Pancreatic ductal adenocarcinoma is extremely aggressivecancer and currently available therapies are only minimallyeffective in treating this disease. Tackling this devastating cancerhas been a major challenge to the scientific and medicalcommunities, in part due to its intense therapeutic resistance.There are numerous aspects of this tumor…