PHYSICAL EXERCISE, BDNF, AND COGNITIVE AGING: MECHANISMS, EVIDENCE, AND CLINICAL IMPLICATIONS

Volume 36, Number 4 (2026)

Kimberley Mvetimbo Tambo, Vaiva Hendrixson Abstract Aim: To review the biological mechanisms, clinical evi­dence, and translational implications of exercise-induced BDNF modulation in the context of cognitive aging, and to examine the role of physical activity as a modifiable lifestyle factor supporting brain health. Methods: A narrative review of current scientific litera­ture was conducted, including experimental…

Impaired Neurogenesis Following Treatment for CNS Malignancies

Volume 23, Number 3(88) (2013)

Aista Plieskienė, Tomas Daukšas Abstract Radiation therapy is common standard treatment method for treatment of central nervous system (CNS) malignancies. The risk associated with this therapeutic modality is neurotoxicity. The literature reviews the mechanisms of radiation induced failure of neurogenesis. Cranial radiation therapy is associated with a progressive decline in cognitive function, prominently memory, specifically…