Anti Braf Therapy for Patients with Metastatic Melanoma. Adverse Eventes

Alvydas Česas, Asta Poškienė, Jolanta Česienė Abstract Melanoma is malignant skin cancer originated from melaninproducing cells. Melanomagenesis is initially triggered byenvironmental agents including ultraviolet (UV), which inducesgenetic/epigenetic alterations in the chromosomes of melanocytes.In human melanomas, the RAS/RAF/MEK/ERK (MAPK) andthe PI3K/PTEN/AKT (AKT) signaling pathways are two majorsignaling pathways and are constitutively activated through geneticalterations. In 2002…