Over the last few decades, in vitro diagnosis of allergic diseases has become an important corner stone. We have learned in recent years that the evaluation of patient’s sensitization pattern is a useful and reproducible tool both clinically and in practice. It has also been found to be particularly useful for diagnosis of infants and children, where the performance of a variety of skin tests might be too traumatic and the description of early sensitization pattern is important for prediction of atopic march and individual risk assessment.
The aim of this study was to evaluate the role of specific IgE detection in children with asthma, rhinitis or dermatitis. 386 children in the age 2-8 year were tested for the eozinophil cell numbers in total blood, total IgE concentration in serum and specific IgE antibodies for 36 food and inhalant allergens. The results show that in 25% of patients was an increased number of eozinofils, 38% of children had an increased concentration of total IgE. In 44,3% of patients specific antibodies to one or several antigens were obtained. This shows that even patients with normal IgE levels and amounts of eozinophil cells can be sensitised to one or more allergents. Therefore an extended repertoire of diagnostic tests, including specific IgE detemination helps to achieve the goal of successful management of allergic astma, rhinitis and atopic dermatitis which is mainly based on accurate diagnosis and individualised treatment.
Keyword(s): allergy, specific IgE, in vitro diagnosis.
Full Text: PDF