Albertas Daukša, Antanas Gulbinas, Aurelija Kazlauskaitė, Johannes Oldenburg, Osman El-Maarri


Gastric cancers are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. Non-invasive early detection would greatly enhance therapy and survival rates. For this aim, we investigated tumor suppressor genes CDKN2A/p16, RARBeta, TNFRSF10C, APC, ACIN1, DAPK1, 3OST2, BCL2 and CD44 for methylation changes in peripheral blood leukocytes of gastric cancer patients. This study shows that methylation changes in peripheral blood leukocyte DNA could provide a promising method for the early detection of gastric cancer. However, larger studies are essential to explore the clinical usefulness of a peripheral blood leukocyte DNA methylation based tests for non-invasive early detection of gastric cancer.

Aricle in Lithuanian

Keyword(s): gastric cancer; methylation; leukocyte; tumor suppressor gene
DOI: 10.5200/sm-hs.2013.046
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