Ugnė Lindžiūtė, Eglė Zlatkutė, Tadas Urbonas, Tomas Bukauskas, Donatas Simonaitis, Andrius Macas


Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are usually used to treat various severity and localization pain. Acceptable postoperative pain management should be acquired to avoid tachycardia, elevated blood pressure, myocardial ischemia, decreased alveolar ventilation, poor healing of wounds. This article puts acetaminophen and lornoxicam in comparison to determine which drug has greater efficacy in postoperative pain management. The aim of the study was to evaluate lornoxicam’s analgesic efficacy in postoperative pain management. Methods: A total of 35 patients after radical prostatectomy were treated in LUHS Kaunas Clinics Urology department. Informed consent was obtained from all patients. Injection of intravenous analgesic drug was randomized and patients received 1000mg acetaminophen or 8mg lornoxicam during radical prostatectomy. Abdominal pain was measured 3, 6, 12 and 24 hours after every surgery. Results: 1 (6.25%) patient in lornoxicam (L) group had abdominal pain before surgery. In acetaminophen (A) group 1 (5.26%) patient had forearm pain. Pain was measured after successful radical prostatectomies. In acetaminophen group, 3 hours after surgery, 9 (47.37%) patients experienced average, 3 (15.79%) severe abdominal pain. In lornoxicam group, 3 hours after surgery, 3 (18,75%) patients experienced severe pain. There was no significant difference between A and L groups, after 3, 6, 12 and 24 hours (p=0.329; p=0.917; p=0.4; p=0.903, respectively). Conclusion: Both intravenous lornoxicam and paracetamol had similar efficacy in postoperative pain management following radical prostatectomies. Intravenous lornoxicam was as effective as intravenous acetaminophen following radical prostatectomies. Both intravenous lornoxicam and paracetamol are suitable to manage average and severe pain during early postoperative period.

Keyword(s): postoperative pain; non-steroidal anti-inflammatory drugs; intravenous lornoxicam; intravenous acetaminophen.
DOI: 10.5200/sm-hs.2017.023
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