EFFECTS OF LOW STATUS OF VITAMIN D ON BONE MINERAL DENSITY AND OSSEOINTEGRATION

Aim. To evaluate the effect of low vitamin D status on bone mineral density and implant osseointegration.

Material and methods. A systematic literature review was performed of observational studies in English identified in MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane Library), Springer Link, Science Direct and Google Scholar databases, publis­hed between 2011 and 2021. Studies had to be perfor­med in vivo.

Results. 135 publications were found, out of which 4 observational studies were identified as relevant to the theme and underwent systematic review: 2 case reports, 1 cross-sectional study and 1 retrospective cohort study.

Conclusion. The published data is not sufficient to con­firm a specific effects of low vitamin D status on bone mineral density and osseointegration. Although, the pu­blished results are promising more prospective rando­mized controlled clinical trials are required in order to confirm the presence of an association between low se­rum levels of vitamin D and an increase in the incidence of early implant failure.