Vita Kvekšaitė, Ieva Vasilavičiūtė, Monika Zinkevičiūtė, Povilas Aniulis, Rosita Aniulienė
Objective. To evaluate and to compare the effectiveness of drugs for overactive bladder and influence of different conditions with OAB in one women outpatient department. Method. 218 cases of women with OAB were analyzed in the retrospective study. Anamnestic information: age, duration of menopause, number of births, history of the diseases and surgical interventions, other comorbidities were included. The rate of OAB symptoms, prescribed medications and effectiveness of treatment were evaluated. Statistical analysis undertaken to analyse baseline demographics, symptoms, comorbidities and other data included the Fisher’s Exact test for categorical values, Student’s Ttest for continuous parametric variables, the Mann Whitney U test for continuous and unpaired non-parametric variables. A p-value of less than 0,05 was considered significant. Results. There was no significant difference of effectiveness of OAB treatment between women with diabetes (p=0,182), hypertension (p=0,717) or TVT-O operations (p=0,348) and women without comorbidities. Any significant relationship between women age (p=0,859), duration of menopause (p=0,03), number of births (p=0,852) and effectiveness of anticholinergic treatment was found. The action of tolterodine increases in women with long duration of menopause (p=0,03), however duration of menopause has no impact on effectiveness of solifenacine (p=0,208). Conclusions. Diabetes and gynecological pathologies have significant impact for OAB symptoms, while other comorbidities do not influence OAB symptoms. There was no significant relationship betweenwomen age, duration of menopause, number of births, comorbidities and effectiveness of OAB treatment.
Keyword(s): overactive bladder syndrome; urinary incontinence; anticholinergic drugs.
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