Viktorija Steponavičiūtė
Abstract
Summary
Objective: To estimate influence of antibiotics dose to postoperative infections frequency.
Methods: This prospective randomized study was performed at obstetrics – gynecology department of Klaipėda University Hospital in 2010. The study data was collected from 511 maternals. All women were divided into two groups. Group 1 received 1 gram of antibiotics before operation. Group 2 received 2 grams of antibiotics. Maternal ages, body mass index, weeks of gestation, the number of pregnancies were compared of each group. Between groups were compared fever, wound infections, postpartum endometritis dependence to antibiotics dose. Statistical calculations were performed using Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA, version 16.0.1.)
Results: 1gram antibiotics before the surgery was assigned to 317 maternal (62.03 percent of all the women surveyed (Group 1)), 2 grams antibiotics to 194 maternal (37.97 percent of all women surveyed (Group 2)). Postnatal endometritis had 25 (7,8 percent) in Group 1 and 17 (8,7 percent) in Group 2 (p = 0,856). Maternal, which before the operation received 1 gram antibiotics, antibiotic treatment in postoperative period needed – 44 (13.88 percent) and those that before the operation received 2 grams – 21 (10.82 percent), (p = 0.313). Fever, in postnatal period, had 27 (8,5 percent) in Group 1 and 15 (7,7 percent) in Group 2, (p = 0,079).
Conclusion: A higher dose of the antibiotic has no significant effect on postnatal endometritis, postoperative fever, and postoperative wound infection.
Keyword(s): antibiotics, sectio caesarea, endometritis, neonatal infection.
DOI: 10.5200/109
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