Aista Plieskienė, Rima Ladygienė, Žygimantas Vaisiūnas, Kamilė Guogytė, Vinsas Janušonis, Julius Žiliukas
Abstract
Radiotherapy is used with curative intention in most cancer patients. Individual radiosensitivity has a crucial impact on radiotherapy related side effects. Analysis of cytogenetic damage in peripheral blood lymphocytes induced by ionizing radiation is commonly used for biodosimetry. The applicability of the available assays is based on the stability of the chromosomal damage.The first Study of individual Radiosensitivity analysis in Cancer Patients in Lithuania was started in 2014 in cooperation of Radiation Protection Centre of Lithuania and Klaipeda university hospital.The aim of the study was to identify a cancer patients for its variation of individual radiosensitivity and to evaluate different cytogenetic techniques for external radiation exposures. It may be useful to develop a simple routine cytogenetic assay which would allow the screening of a large number of individuals for radiosensitivity optimizing tumor control rates and minimizing severe radiotherapy effects with possibility to predict risk level for developing more severe early normal tissue adverse events after irradiation. The cytogenetic context, retrospective dosimetry often refers to stable endpoints, i.e. those which persist long enough to identify chromosomal damage. Acknowledgments. This research is carried out under the contract “Possibility for optimization of patient doses in radiotherapy due to identification of radiation sensitive patients using cytogenetic methods” which is part of the International Atomic Energy Agency (IAEA) Coordinated Research Project “Strengthening of “Biological dosimetry” in IAEA Member States: Improvement of current techniques and intensification of collaboration and networking among the different institutes” [CRP: E3.50.08].
Keyword(s): radiotherapy; radiosensitivity.
DOI: 10.5200/sm-hs.2015.072
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